About Steroidogenic factor 1
Steroidogenic factor 1 (NR5A1) is a protein
from Homo sapiens identified by UniProt accession
Q13285, 461 residues long.
MolForge cross-references it against 0 known binders and
358 disease associations.
Target properties
| Protein name | Steroidogenic factor 1 |
|---|
| UniProt accession | Q13285 |
|---|
| Gene | NR5A1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 461 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (358)
Diseases linked to this target (Open Targets).
- 46,XY sex reversal 3 · score 0.79
- premature ovarian failure 7 · score 0.76
- spermatogenic failure 8 · score 0.74
- primary ovarian insufficiency · score 0.65
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.65
- 46,XX testicular disorder of sex development · score 0.56
- 46,XY disorder of sex development · score 0.55
- disorder of sexual differentiation · score 0.51
- genetic non-acquired premature ovarian failure · score 0.49
- Genetic 46,XY disorder of sex development · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13285-F1 | alphafold | PREDICTED | 77.83 | — |
Amino-acid sequence (461 residues)
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQSCKIDKT QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL ETGPPMGVPP PPPPAPDYVL PPSLHGPEPK GLAAGPPAGP LGDFGAPALP MAVPGAHGPL AGYLYPAFPG RAIKSEYPEP YASPPQPGLP YGYPEPFSGG PNVPELILQL LQLEPDEDQV RARILGCLQE PTKSRPDQPA AFGLLCRMAD QTFISIVDWA RRCMVFKELE VADQMTLLQN CWSELLVFDH IYRQVQHGKE GSILLVTGQE VELTTVATQA GSLLHSLVLR AQELVLQLLA LQLDRQEFVC LKFIILFSLD LKFLNNHILV KDAQEKANAA LLDYTLCHYP HCGDKFQQLL LCLVEVRALS MQAKEYLYHK HLGNEMPRNN LLIEMLQAKQ T
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