Signaling lymphocytic activation molecule (SLAMF1)

About Signaling lymphocytic activation molecule

Signaling lymphocytic activation molecule (SLAMF1) is a protein from Homo sapiens identified by UniProt accession Q13291, 335 residues long. MolForge cross-references it against 0 known binders and 194 disease associations.

Target properties

Protein name	Signaling lymphocytic activation molecule
UniProt accession	Q13291
Gene	SLAMF1
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (194)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.40
eosinophil percentage of leukocytes · score 0.32
cognitive decline measurement · score 0.28
memory performance · score 0.28
PHF-tau measurement · score 0.23
blood protein measurement · score 0.20
mosquito bite reaction itch intensity measurement · score 0.14
inflammatory bowel disease · score 0.14
chronic lymphocytic leukemia · score 0.09
infection · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13291-F1	alphafold	PREDICTED	74.92	—

Amino-acid sequence (335 residues)

MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV YAGLLGGVIM ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards