About Uracil nucleotide/cysteinyl leukotriene receptor
Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) is a protein
from Homo sapiens identified by UniProt accession
Q13304, 367 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Uracil nucleotide/cysteinyl leukotriene receptor |
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| UniProt accession | Q13304 |
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| Gene | GPR17 |
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| Organism | Homo sapiens |
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| Length | 367 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- glioblastoma multiforme · score 0.28
- myeloid white cell count · score 0.24
- breast adenocarcinoma · score 0.24
- leukocyte count · score 0.16
- cutaneous melanoma · score 0.13
- autosomal recessive limb-girdle muscular dystrophy · score 0.12
- autosomal recessive limb-girdle muscular dystrophy type 2W · score 0.12
- prostate adenocarcinoma · score 0.10
- periventricular leukomalacia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13304-F1 | alphafold | PREDICTED | 80.31 | — |
Amino-acid sequence (367 residues)
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC AFLWVVVAVA MAPLLVSPQT VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS LSAKSEL
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