S-phase kinase-associated protein 2 (SKP2)

About S-phase kinase-associated protein 2

S-phase kinase-associated protein 2 (SKP2) is a protein from Homo sapiens identified by UniProt accession Q13309, 424 residues long. MolForge cross-references it against 0 known binders and 262 disease associations.

Target properties

Protein name	S-phase kinase-associated protein 2
UniProt accession	Q13309
Gene	SKP2
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (262)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
mean corpuscular volume · score 0.49
multiple sclerosis · score 0.43
Alzheimer disease · score 0.43
Parkinson disease · score 0.43
lysosomal storage disease · score 0.43
Red cell distribution width · score 0.43
mean corpuscular hemoglobin concentration · score 0.39
appendicular lean mass · score 0.39
mean reticulocyte volume · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13309-F1	alphafold	PREDICTED	82.13	—

Amino-acid sequence (424 residues)

MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV SGVCKRWYRL ASDESLWQTL DLTGKNLHPD VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP FRVQHMDLSN SVIEVSTLHG ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC SGFSEFALQT LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP ETLLELGEIP TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT IGNKKNQEIW GIKCRLTLQK PSCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards