About Polyadenylate-binding protein 4
Polyadenylate-binding protein 4 (PABPC4) is a protein
from Homo sapiens identified by UniProt accession
Q13310, 644 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Polyadenylate-binding protein 4 |
|---|
| UniProt accession | Q13310 |
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| Gene | PABPC4 |
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| Organism | Homo sapiens |
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| Length | 644 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (95)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.43
- Red cell distribution width · score 0.42
- C-reactive protein measurement · score 0.41
- mean corpuscular hemoglobin concentration · score 0.41
- mean corpuscular hemoglobin · score 0.40
- sex hormone-binding globulin measurement · score 0.38
- type 2 diabetes mellitus · score 0.37
- FEV/FVC ratio · score 0.37
- mean corpuscular volume · score 0.37
- bilirubin measurement · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13310-F1 | alphafold | PREDICTED | 75.82 | — |
Amino-acid sequence (644 residues)
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF GGAGAAQQGL TDSCQSGGVP TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ APQPAVHVQG QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS
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