About Dentin matrix acidic phosphoprotein 1
Dentin matrix acidic phosphoprotein 1 (DMP1) is a protein
from Homo sapiens identified by UniProt accession
Q13316, 513 residues long.
MolForge cross-references it against 0 known binders and
585 disease associations.
Target properties
| Protein name | Dentin matrix acidic phosphoprotein 1 |
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| UniProt accession | Q13316 |
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| Gene | DMP1 |
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| Organism | Homo sapiens |
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| Length | 513 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (585)
Diseases linked to this target (Open Targets).
- autosomal recessive hypophosphatemic rickets · score 0.63
- hypophosphatemic rickets · score 0.41
- lean body mass · score 0.39
- acromesomelic dysplasia 2A · score 0.38
- acromesomelic dysplasia 2C, Hunter-Thompson type · score 0.38
- Acromesomelic dysplasia, Grebe type · score 0.38
- osteoarthritis · score 0.37
- acromesomelic dysplasia 2B · score 0.37
- brachydactyly type A2 · score 0.37
- Skeletal dysplasia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13316-F1 | alphafold | PREDICTED | 47.64 | — |
Amino-acid sequence (513 residues)
MKISILLMFL WGLSCALPVT RYQNNESEDS EEWKGHLAQA PTPPLESSES SEGSKVSSEE QANEDPSDST QSEEGLGSDD HQYIYRLAGG FSRSTGKGGD DKDDDEDDSG DDTFGDDDSG PGPKDRQEGG NSRLGSDEDS DDTIQASEES APQGQDSAQD TTSESRELDN EDRVDSKPEG GDSTQESESE EHWVGGGSDG ESSHGDGSEL DDEGMQSDDP ESIRSERGNS RMNSAGMKSK ESGENSEQAN TQDSGGSQLL EHPSRKIFRK SRISEEDDRS ELDDNNTMEE VKSDSTENSN SRDTGLSQPR RDSKGDSQED SKENLSQEES QNVDGPSSES SQEANLSSQE NSSESQEEVV SESRGDNPDP TTSYVEDQED SDSSEEDSSH TLSHSKSESR EEQADSESSE SLNFSEESPE SPEDENSSSQ EGLQSHSSSA ESQSEESHSE EDDSDSQDSS RSKEDSNSTE SKSSSEEDGQ LKNIEIESRK LTVDAYHNKP IGDQDDNDCQ DGY
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