About Growth factor receptor-bound protein 10
Growth factor receptor-bound protein 10 (GRB10) is a protein
from Homo sapiens identified by UniProt accession
Q13322, 594 residues long.
MolForge cross-references it against 0 known binders and
192 disease associations.
Target properties
| Protein name | Growth factor receptor-bound protein 10 |
|---|
| UniProt accession | Q13322 |
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| Gene | GRB10 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 594 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (192)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- refractive error measurement · score 0.44
- body height · score 0.43
- glucose measurement · score 0.43
- eosinophil count · score 0.43
- neuroimaging measurement · score 0.43
- appendicular lean mass · score 0.42
- self reported educational attainment · score 0.42
- brain volume measurement · score 0.41
- glomerular filtration rate · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13322-F1 | alphafold | PREDICTED | 73.86 | — |
Amino-acid sequence (594 residues)
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL
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