About Bcl-2-interacting killer
Bcl-2-interacting killer (BIK) is a protein
from Homo sapiens identified by UniProt accession
Q13323, 160 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Bcl-2-interacting killer |
|---|
| UniProt accession | Q13323 |
|---|
| Gene | BIK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 160 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- prostate carcinoma · score 0.42
- mitochondrial DNA measurement · score 0.33
- erythrocyte count · score 0.31
- total blood protein measurement · score 0.28
- serum non-albumin protein measurement · score 0.28
- red blood cell density measurement · score 0.27
- mean platelet volume · score 0.25
- platelet component distribution width · score 0.25
- mean corpuscular hemoglobin · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13323-F1 | alphafold | PREDICTED | 62.50 | — |
Amino-acid sequence (160 residues)
MSEVRPLSRD ILMETLLYEQ LLEPPTMEVL GMTDSEEDLD PMEDFDSLEC MEGSDALALR LACIGDEMDV SLRAPRLAQL SEVAMHSLGL AFIYDQTEDI RDVLRSFMDG FTTLKENIMR FWRSPNPGSW VSCEQVLLAL LLLLALLLPL LSGGLHLLLK
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