Gamma-sarcoglycan (SGCG)

About Gamma-sarcoglycan

Gamma-sarcoglycan (SGCG) is a protein from Homo sapiens identified by UniProt accession Q13326, 291 residues long. MolForge cross-references it against 0 known binders and 884 disease associations.

Target properties

Protein name	Gamma-sarcoglycan
UniProt accession	Q13326
Gene	SGCG
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (884)

Diseases linked to this target (Open Targets).

autosomal recessive limb-girdle muscular dystrophy type 2C · score 0.80
autosomal recessive limb-girdle muscular dystrophy · score 0.61
type 2 diabetes mellitus · score 0.39
limb-girdle muscular dystrophy · score 0.37
Abnormality of the musculature · score 0.34
neurofibrillary tangles measurement · score 0.30
arterial stiffness measurement · score 0.25
drug use measurement · score 0.23
protein measurement · score 0.22
atrial fibrillation · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13326-F1	alphafold	PREDICTED	80.29	—

Amino-acid sequence (291 residues)

MVREQYTTAT EGICIERPEN QYVYKIGIYG WRKRCLYLFV LLLLIILVVN LALTIWILKV MWFSPAGMGH LCVTKDGLRL EGESEFLFPL YAKEIHSRVD SSLLLQSTQN VTVNARNSEG EVTGRLKVGP KMVEVQNQQF QINSNDGKPL FTVDEKEVVV GTDKLRVTGP EGALFEHSVE TPLVRADPFQ DLRLESPTRS LSMDAPRGVH IQAHAGKIEA LSQMDILFHS SDGMLVLDAE TVCLPKLVQG TWGPSGSSQS LYEICVCPDG KLYLSVAGVS TTCQEHNHIC L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards