About Metastasis-associated protein MTA1
Metastasis-associated protein MTA1 (MTA1) is a protein
from Homo sapiens identified by UniProt accession
Q13330, 715 residues long.
MolForge cross-references it against 0 known binders and
213 disease associations.
Target properties
| Protein name | Metastasis-associated protein MTA1 |
|---|
| UniProt accession | Q13330 |
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| Gene | MTA1 |
|---|
| Organism | Homo sapiens |
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| Length | 715 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (213)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- blood protein measurement · score 0.34
- endometrial cancer · score 0.28
- breast adenocarcinoma · score 0.27
- glioblastoma multiforme · score 0.24
- esophageal cancer · score 0.23
- lung adenocarcinoma · score 0.19
- gastric adenocarcinoma · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- squamous cell lung carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13330-F1 | alphafold | PREDICTED | 72.11 | — |
Amino-acid sequence (715 residues)
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSTLIALAD KHATLSVCYK AGPGADNGEE GEIEEEMENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL LKEGEEDGRD QSRLETQVWE AHNPLTDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN KPNPNQISVN NVKAGVVNGT GAPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRSNMSP HGLPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY LPINSAAIKA ECTARLPEAS QSPLVLKQAV RKPLEAVLRY LETHPRPPKP DPVKSVSSVL SSLTPAKVAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL MPSRGLANHG QARHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP PPPAPVNDEP IVIED
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