About Receptor-type tyrosine-protein phosphatase S
Receptor-type tyrosine-protein phosphatase S (PTPRS) is a protein
from Homo sapiens identified by UniProt accession
Q13332, 1948 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Receptor-type tyrosine-protein phosphatase S |
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| UniProt accession | Q13332 |
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| Gene | PTPRS |
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| Organism | Homo sapiens |
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| Length | 1948 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- multiple sclerosis · score 0.32
- Alzheimer disease · score 0.32
- lysosomal storage disease · score 0.32
- Parkinson disease · score 0.32
- neurofibrillary tangles measurement · score 0.32
- drug-induced mental disorder · score 0.32
- body weight · score 0.32
- body mass index · score 0.31
- NK-cell enteropathy · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13332-F1 | alphafold | PREDICTED | 81.49 | — |
Amino-acid sequence (1948 residues)
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT
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