About Urea transporter 1
Urea transporter 1 (SLC14A1) is a protein
from Homo sapiens identified by UniProt accession
Q13336, 389 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Urea transporter 1 |
|---|
| UniProt accession | Q13336 |
|---|
| Gene | SLC14A1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 389 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (260)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.49
- hematocrit · score 0.43
- reticulocyte count · score 0.41
- Immature Reticulocyte Fraction Measurement · score 0.41
- reticulocyte measurement · score 0.40
- urinary bladder carcinoma · score 0.40
- mean reticulocyte volume · score 0.34
- mean corpuscular volume · score 0.33
- serum urea measurement · score 0.30
- PHF-tau measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13336-F1 | alphafold | PREDICTED | 92.97 | — |
Amino-acid sequence (389 residues)
MEDSPTMVRV DSPTMVRGEN QVSPCQGRRC FPKALGYVTG DMKELANQLK DKPVVLQFID WILRGISQVV FVNNPVSGIL ILVGLLVQNP WWALTGWLGT VVSTLMALLL SQDRSLIASG LYGYNATLVG VLMAVFSDKG DYFWWLLLPV CAMSMTCPIF SSALNSMLSK WDLPVFTLPF NMALSMYLSA TGHYNPFFPA KLVIPITTAP NISWSDLSAL ELLKSIPVGV GQIYGCDNPW TGGIFLGAIL LSSPLMCLHA AIGSLLGIAA GLSLSAPFED IYFGLWGFNS SLACIAMGGM FMALTWQTHL LALGCALFTA YLGVGMANFM AEVGLPACTW PFCLATLLFL IMTTKNSNIY KMPLSKVTYP EENRIFYLQA KKRMVESPL
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