Krueppel-like factor 1 (KLF1)

About Krueppel-like factor 1

Krueppel-like factor 1 (KLF1) is a protein from Homo sapiens identified by UniProt accession Q13351, 362 residues long. MolForge cross-references it against 0 known binders and 276 disease associations.

Target properties

Protein name	Krueppel-like factor 1
UniProt accession	Q13351
Gene	KLF1
Organism	Homo sapiens
Length	362 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (276)

Diseases linked to this target (Open Targets).

congenital dyserythropoietic anemia type 4 · score 0.77
mean corpuscular volume · score 0.69
Congenital dyserythropoietic anemia type IV · score 0.69
mean corpuscular hemoglobin · score 0.66
Red cell distribution width · score 0.65
erythrocyte count · score 0.55
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.54
mean corpuscular hemoglobin concentration · score 0.52
hemoglobin measurement · score 0.50
Hydrops fetalis · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13351-F1	alphafold	PREDICTED	56.98	—

Amino-acid sequence (362 residues)

MATAETALPS ISTLTALGPF PDTQDDFLKW WRSEEAQDMG PGPPDPTEPP LHVKSEDQPG EEEDDERGAD ATWDLDLLLT NFSGPEPGGA PQTCALAPSE ASGAQYPPPP ETLGAYAGGP GLVAGLLGSE DHSGWVRPAL RARAPDAFVG PALAPAPAPE PKALALQPVY PGPGAGSSGG YFPRTGLSVP AASGAPYGLL SGYPAMYPAP QYQGHFQLFR GLQGPAPGPA TSPSFLSCLG PGTVGTGLGG TAEDPGVIAE TAPSKRGRRS WARKRQAAHT CAHPGCGKSY TKSSHLKAHL RTHTGEKPYA CTWEGCGWRF ARSDELTRHY RKHTGQRPFR CQLCPRAFSR SDHLALHMKR HL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards