RING-type E3 ubiquitin-protein ligase PPIL2 (PPIL2)

About RING-type E3 ubiquitin-protein ligase PPIL2

RING-type E3 ubiquitin-protein ligase PPIL2 (PPIL2) is a protein from Homo sapiens identified by UniProt accession Q13356, 520 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	RING-type E3 ubiquitin-protein ligase PPIL2
UniProt accession	Q13356
Gene	PPIL2
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
vital capacity · score 0.16
body height · score 0.16
mean corpuscular hemoglobin · score 0.14
mean corpuscular volume · score 0.12
head and neck squamous cell carcinoma · score 0.11
age at menarche · score 0.02
cancer · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13356-F1	alphafold	PREDICTED	81.05	—

Amino-acid sequence (520 residues)

MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK IIDPDEEKAK QDPSYYLKNT NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH YSTGKVSASF TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV GKYINPAATK RAAEEEPSTS ATVPMSKKKP SRGFGDFSSW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards