About Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) is a protein
from Homo sapiens identified by UniProt accession
Q13362, 524 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform |
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| UniProt accession | Q13362 |
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| Gene | PPP2R5C |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- cancer · score 0.53
- neurodegenerative disease · score 0.48
- chronic myelogenous leukemia · score 0.38
- thyroid gland adenocarcinoma · score 0.30
- breast adenocarcinoma · score 0.30
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- gut microbiome measurement · score 0.28
- body fat percentage · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13362-F1 | alphafold | PREDICTED | 84.41 | — |
Amino-acid sequence (524 residues)
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR
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