C-terminal-binding protein 1 (CTBP1)

About C-terminal-binding protein 1

C-terminal-binding protein 1 (CTBP1) is a protein from Homo sapiens identified by UniProt accession Q13363, 440 residues long. MolForge cross-references it against 0 known binders and 249 disease associations.

Target properties

Protein name	C-terminal-binding protein 1
UniProt accession	Q13363
Gene	CTBP1
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (249)

Diseases linked to this target (Open Targets).

hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome · score 0.65
genetic disorder · score 0.41
type 2 diabetes mellitus · score 0.39
Drugs used in diabetes use measurement · score 0.31
Intellectual disability · score 0.27
glucose measurement · score 0.25
endometrial cancer · score 0.25
pulse pressure measurement · score 0.24
thyroid gland adenocarcinoma · score 0.23
attention deficit hyperactivity disorder · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13363-F1	alphafold	PREDICTED	83.28	—

Amino-acid sequence (440 residues)

MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA PSPGQTVKPE ADRDHASDQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards