About C-Jun-amino-terminal kinase-interacting protein 2
C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) is a protein
from Homo sapiens identified by UniProt accession
Q13387, 824 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | C-Jun-amino-terminal kinase-interacting protein 2 |
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| UniProt accession | Q13387 |
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| Gene | MAPK8IP2 |
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| Organism | Homo sapiens |
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| Length | 824 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.06
- neoplasm · score 0.05
- male infertility with teratozoospermia due to single gene mutation · score 0.04
- spermatogenic failure 61 · score 0.04
- spermatogenic failure 59 · score 0.04
- spermatogenic failure 73 · score 0.04
- spermatogenic failure 74 · score 0.04
- spermatogenic failure 72 · score 0.04
- spermatogenic failure 20 · score 0.04
- spermatogenic failure 46 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13387-F1 | alphafold | PREDICTED | 51.34 | — |
Amino-acid sequence (824 residues)
MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE EEEGDGEGQE GGDPGSEAPA PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD SLNNNGGFDL VRPASWQETA LCSPAPEALR ELPGPLPATD TGPGGAQSPV RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR GGRRSSQELS SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL LSNLVSRMIS EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA AGPGGVELVD METLCAPPPP APAAPRPGPA QPGPCLFLSN PTRDTITPLW AAPGRAARPG RACSAACSEE EDEEDDEEEE DAEDSAGSPG GRGTGPSAPR DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS GGEASEEEAG AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG ERGVFPAFYA HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG ILCAAMQKIA TARKLTVHLR PPASCDLEIS LRGVKLSLSG GGPEFQRCSH FFQMKNISFC GCHPRNSCYF GFITKHPLLS RFACHVFVSQ ESMRPVAQSV GRAFLEYYQE HLAYACPTED IYLE
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