Large ribosomal subunit protein mL49 (MRPL49)

About Large ribosomal subunit protein mL49

Large ribosomal subunit protein mL49 (MRPL49) is a protein from Homo sapiens identified by UniProt accession Q13405, 166 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Large ribosomal subunit protein mL49
UniProt accession	Q13405
Gene	MRPL49
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
platelet crit · score 0.02
chronic hepatitis B virus infection · score 0.02
neoplasm · score 0.01
achromatopsia · score 0.01
infect · score 0.01
infection · score 0.01
renal cell carcinoma · score 0.00
prostate adenocarcinoma · score 0.00
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13405-F1	alphafold	PREDICTED	84.54	—

Amino-acid sequence (166 residues)

MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK GYFDQELKAW LLEKGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards