About Cytoplasmic dynein 1 intermediate chain 2
Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) is a protein
from Homo sapiens identified by UniProt accession
Q13409, 638 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Cytoplasmic dynein 1 intermediate chain 2 |
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| UniProt accession | Q13409 |
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| Gene | DYNC1I2 |
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| Organism | Homo sapiens |
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| Length | 638 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly and structural brain anomalies · score 0.70
- neurodegenerative disease · score 0.48
- viral disease · score 0.46
- lysosomal storage disease · score 0.43
- neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies · score 0.43
- Parkinson disease · score 0.32
- multiple sclerosis · score 0.32
- Alzheimer disease · score 0.32
- body mass index · score 0.30
- breast adenocarcinoma · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13409-F1 | alphafold | PREDICTED | 72.67 | — |
Amino-acid sequence (638 residues)
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG SQDSGDGAVG SRTLHWDTDP SVLQLHSDSD LGRGPIKLGM AKITQVDFPP REIVTYTKET QTPVMAQPKE DEEEDDDVVA PKPPIEPEEE KTLKKDEEND SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ INIFFDYSGR DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG GTYSGQIVLW DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS ISTDGKICSW SLDMLSHPQD SMELVHKQSK AVAVTSMSFP VGDVNNFVVG SEEGSVYTAC RHGSKAGISE MFEGHQGPIT GIHCHAAVGA VDFSHLFVTS SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF ACVDGMGRLD LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA
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