About Mesothelin
Mesothelin (MSLN) is a protein
from Homo sapiens identified by UniProt accession
Q13421, 630 residues long.
MolForge cross-references it against 0 known binders and
276 disease associations.
Target properties
| Protein name | Mesothelin |
|---|
| UniProt accession | Q13421 |
|---|
| Gene | MSLN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 630 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (276)
Diseases linked to this target (Open Targets).
- cancer antigen 125 measurement · score 0.30
- erythrocyte count · score 0.19
- neoplasm · score 0.14
- mesothelioma · score 0.13
- malignant pleural mesothelioma · score 0.12
- pancreatic carcinoma · score 0.11
- triple-negative breast cancer · score 0.10
- acute myeloid leukemia · score 0.10
- pancreatic neoplasm · score 0.10
- Miyoshi myopathy · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13421-F1 | alphafold | PREDICTED | 78.64 | — |
Amino-acid sequence (630 residues)
MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ APRRPLPQVA TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ LDVLYPKARL AFQNMNGSEY FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL PLTVAEVQKL LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS MQEALSGTPC LLGPGPVLTV LALLLASTLA
Explore Mesothelin with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets