DNA-binding protein Ikaros (IKZF1)

About DNA-binding protein Ikaros

DNA-binding protein Ikaros (IKZF1) is a protein from Homo sapiens identified by UniProt accession Q13422, 519 residues long. MolForge cross-references it against 0 known binders and 850 disease associations.

Target properties

Protein name	DNA-binding protein Ikaros
UniProt accession	Q13422
Gene	IKZF1
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (850)

Diseases linked to this target (Open Targets).

pancytopenia due to IKZF1 mutations · score 0.79
acute lymphoblastic leukemia · score 0.71
T-cell acute lymphoblastic leukemia · score 0.57
common variable immunodeficiency · score 0.56
B-cell acute lymphoblastic leukemia · score 0.56
monocyte count · score 0.51
mean corpuscular volume · score 0.51
monocyte percentage of leukocytes · score 0.50
eosinophil count · score 0.50
neutrophil count · score 0.50

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13422-F1	alphafold	PREDICTED	47.74	—

Amino-acid sequence (519 residues)

MDADEGQDMS QVSGKESPPV SDTPDEGDEP MPIPEDLSTT SGGQQSSKSD RVVASNVKVE TQSDEENGRA CEMNGEECAE DLRMLDASGE KMNGSHRDQG SSALSGVGGI RLPNGKLKCD ICGIICIGPN VLMVHKRSHT GERPFQCNQC GASFTQKGNL LRHIKLHSGE KPFKCHLCNY ACRRRDALTG HLRTHSVGKP HKCGYCGRSY KQRSSLEEHK ERCHNYLESM GLPGTLYPVI KEETNHSEMA EDLCKIGSER SLVLDRLASN VAKRKSSMPQ KFLGDKGLSD TPYDSSASYE KENEMMKSHV MDQAINNAIN YLGAESLRPL VQTPPGGSEV VPVISPMYQL HKPLAEGTPR SNHSAQDSAV ENLLLLSKAK LVPSEREASP SNSCQDSTDT ESNNEEQRSG LIYLTNHIAP HARNGLSLKE EHRAYDLLRA ASENSQDALR VVSTSGEQMK VYKCEHCRVL FLDHVMYTIH MGCHGFRDPF ECNMCGYHSQ DRYEFSSHIT RGEHRFHMS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards