DNA repair protein XRCC4 (XRCC4)

About DNA repair protein XRCC4

DNA repair protein XRCC4 (XRCC4) is a protein from Homo sapiens identified by UniProt accession Q13426, 336 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	DNA repair protein XRCC4
UniProt accession	Q13426
Gene	XRCC4
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (151)

Diseases linked to this target (Open Targets).

microcephalic primordial dwarfism-insulin resistance syndrome · score 0.73
neurodegenerative disease · score 0.53
isolated growth hormone deficiency type IA · score 0.46
HIV infection · score 0.46
electrocardiography · score 0.42
heel bone mineral density · score 0.37
microcephalic primordial dwarfism · score 0.37
Non-acquired isolated growth hormone deficiency · score 0.33
balding measurement · score 0.27
breast adenocarcinoma · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13426-F1	alphafold	PREDICTED	74.79	—

Amino-acid sequence (336 residues)

MERKISRIHL VSEPSITHFL QVSWEKTLES GFVITLTDGH SAWTGTVSES EISQEADDMA MEKGKYVGEL RKALLSGAGP ADVYTFNFSK ESCYFFFEKN LKDVSFRLGS FNLEKVENPA EVIRELICYC LDTIAENQAK NEHLQKENER LLRDWNDVQG RFEKCVSAKE ALETDLYKRF ILVLNEKKTK IRSLHNKLLN AAQEREKDIK QEGETAICSE MTADRDPVYD ESTDEESENQ TDLSGLASAA VSKDDSIISS LDVTDIAPSR KRRQRMQRNL GTEPKMAPQE NQLQEKENSR PDSSLPETSK KEHISAENMS LETLRNSSPE DLFDEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards