About Peptidyl-prolyl cis-trans isomerase G
Peptidyl-prolyl cis-trans isomerase G (PPIG) is a protein
from Homo sapiens identified by UniProt accession
Q13427, 754 residues long.
MolForge cross-references it against 0 known binders and
531 disease associations.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase G |
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| UniProt accession | Q13427 |
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| Gene | PPIG |
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| Organism | Homo sapiens |
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| Length | 754 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (531)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- neurodegenerative disease · score 0.15
- systolic blood pressure · score 0.14
- cystitis · score 0.11
- hepatocellular carcinoma · score 0.08
- hereditary spastic paraplegia · score 0.08
- neoplasm · score 0.07
- diabetes mellitus · score 0.07
- myeloproliferative disorder · score 0.06
- chronic myeloproliferative disorder · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13427-F1 | alphafold | PREDICTED | 57.06 | — |
Amino-acid sequence (754 residues)
MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD AASKPFAEVR ILSCGELIPK SKVKKEEKKR HKSSSSSSSS SSDSDSSSDS QSSSDSSDSE SATEEKSKKR KKKHRKNSRK HKKEKKKRKK SKKSASSESE AENLEAQPQS TVRPEEIPPI PENRFLMRKS PPKADEKERK NREREREREC NPPNSQPASY QRRLLVTRSG RKIKGRGPRR YRTPSRSRSR DRFRRSETPP HWRQEMQRAQ RMRVSSGERW IKGDKSELNE IKENQRSPVR VKERKITDHR NVSESPNRKN EKEKKVKDHK SNSKERDIRR NSEKDDKYKN KVKKRAKSKS RSKSKEKSKS KERDSKHNRN EEKRMRSRSK GRDHENVKEK EKQSDSKGKD QERSRSKEKS KQLESKSNEH DHSKSKEKDR RAQSRSRECD ITKGKHSYNS RTRERSRSRD RSRRVRSRTH DRDRSRSKEY HRYREQEYRR RGRSRSRERR TPPGRSRSKD RRRRRRDSRS SEREESQSRN KDKYRNQESK SSHRKENSES EKRMYSKSRD HNSSNNSREK KADRDQSPFS KIKQSSQDNE LKSSMLKNKE DEKIRSSVEK ENQKSKGQEN DHVHEKNKKF DHESSPGTDE DKSG
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