About Protein unc-119 homolog A
Protein unc-119 homolog A (UNC119) is a protein
from Homo sapiens identified by UniProt accession
Q13432, 240 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Protein unc-119 homolog A |
|---|
| UniProt accession | Q13432 |
|---|
| Gene | UNC119 |
|---|
| Organism | Homo sapiens |
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| Length | 240 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (135)
Diseases linked to this target (Open Targets).
- idiopathic CD4 lymphocytopenia · score 0.48
- Cone rod dystrophy · score 0.43
- neurodegenerative disease · score 0.31
- Macular dystrophy · score 0.26
- cone-rod dystrophy · score 0.19
- X-linked retinal dysplasia · score 0.08
- retinitis pigmentosa · score 0.08
- age-related macular degeneration · score 0.08
- choroidal dystrophy, central areolar, 1 · score 0.08
- Familial exudative vitreoretinopathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13432-F1 | alphafold | PREDICTED | 77.88 | — |
Amino-acid sequence (240 residues)
MKVKKGGGGA GTATESAPGP SGQSVAPIPQ PPAESESGSE SEPDAGPGPR PGPLQRKQPI GPEDVLGLQR ITGDYLCSPE ENIYKIDFVR FKIRDMDSGT VLFEIKKPPV SERLPINRRD LDPNAGRFVR YQFTPAFLRL RQVGATVEFT VGDKPVNNFR MIERHYFRNQ LLKSFDFHFG FCIPSSKNTC EHIYDFPPLS EELISEMIRH PYETQSDSFY FVDDRLVMHN KADYSYSGTP
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