Golgin subfamily A member 4 (GOLGA4)

About Golgin subfamily A member 4

Golgin subfamily A member 4 (GOLGA4) is a protein from Homo sapiens identified by UniProt accession Q13439, 2230 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Golgin subfamily A member 4
UniProt accession	Q13439
Gene	GOLGA4
Organism	Homo sapiens
Length	2230 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

cancer · score 0.46
total blood protein measurement · score 0.21
pulse pressure measurement · score 0.21
neurodegenerative disease · score 0.19
drug use measurement · score 0.15
atopic eczema · score 0.14
Familial short QT syndrome · score 0.08
cortical thickness · score 0.08
Brugada syndrome · score 0.08
hypertrophic cardiomyopathy · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13439-F1	alphafold	PREDICTED	66.61	—

Amino-acid sequence (2230 residues)

MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT TVGTPYKGGN LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT VLKFPDDQTQ KILEREDARL MFTSPRSGIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards