About Peptidyl-prolyl cis-trans isomerase FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) is a protein
from Homo sapiens identified by UniProt accession
Q13451, 457 residues long.
MolForge cross-references it against 0 known binders and
332 disease associations.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase FKBP5 |
|---|
| UniProt accession | Q13451 |
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| Gene | FKBP5 |
|---|
| Organism | Homo sapiens |
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| Length | 457 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (332)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.44
- BMI-adjusted waist circumference · score 0.37
- BMI-adjusted waist-hip ratio · score 0.36
- leukocyte count · score 0.36
- vital capacity · score 0.35
- eosinophil percentage of leukocytes · score 0.31
- birth weight · score 0.31
- eosinophil count · score 0.30
- forced expiratory volume · score 0.28
- monocyte percentage of leukocytes · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13451-F1 | alphafold | PREDICTED | 92.51 | — |
Amino-acid sequence (457 residues)
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV
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