Forkhead box protein E3 (FOXE3)

About Forkhead box protein E3

Forkhead box protein E3 (FOXE3) is a protein from Homo sapiens identified by UniProt accession Q13461, 319 residues long. MolForge cross-references it against 0 known binders and 646 disease associations.

Target properties

Protein name	Forkhead box protein E3
UniProt accession	Q13461
Gene	FOXE3
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (646)

Diseases linked to this target (Open Targets).

congenital primary aphakia · score 0.82
anterior segment dysgenesis · score 0.73
cataract 34 multiple types · score 0.70
Familial ocular anterior segment mesenchymal dysgenesis · score 0.65
Ocular anterior segment dysgenesis · score 0.64
Posterior polar cataract · score 0.63
familial thoracic aortic aneurysm and aortic dissection · score 0.51
neurodegenerative disease · score 0.45
Peters anomaly · score 0.39
Developmental cataract · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13461-F1	alphafold	PREDICTED	65.02	—

Amino-acid sequence (319 residues)

MAGRSDMDPP AAFSGFPALP AVAPSGPPPS PLAGAEPGRE PEEAAAGRGE AAPTPAPGPG RRRRRPLQRG KPPYSYIALI AMALAHAPGR RLTLAAIYRF ITERFAFYRD SPRKWQNSIR HNLTLNDCFV KVPREPGNPG KGNYWTLDPA AADMFDNGSF LRRRKRFKRA ELPAHAAAAP GPPLPFPYAP YAPAPGPALL VPPPSAGPGP SPPARLFSVD SLVNLQPELA GLGAPEPPCC AAPDAAAAAF PPCAAAASPP LYSQVPDRLV LPATRPGPGP LPAEPLLALA GPAAALGPLS PGEAYLRQPG FASGLERYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards