About Frizzled-5
Frizzled-5 (FZD5) is a protein
from Homo sapiens identified by UniProt accession
Q13467, 585 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Frizzled-5 |
|---|
| UniProt accession | Q13467 |
|---|
| Gene | FZD5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 585 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (89)
Diseases linked to this target (Open Targets).
- coloboma · score 0.44
- hemoglobin measurement · score 0.41
- coloboma of choroid and retina · score 0.37
- coloboma of eyelid · score 0.37
- Coloboma of optic papilla · score 0.37
- coloboma of macula · score 0.37
- coloboma of eye lens · score 0.37
- coloboma of iris · score 0.37
- neurodegenerative disease · score 0.36
- hematocrit · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13467-F1 | alphafold | PREDICTED | 81.61 | — |
Amino-acid sequence (585 residues)
MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH MPNQFNHDTQ DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG RDAEVLCMDY NRSEATTAPP RPFPAKPTLP GPPGAPASGG ECPAGGPFVC KCREPFVPIL KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG LWSVLCFIST STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGHD TGQPRAKPEY WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR PRRGHKSGGA MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV
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