About Non-receptor tyrosine-protein kinase TNK1
Non-receptor tyrosine-protein kinase TNK1 (TNK1) is a protein
from Homo sapiens identified by UniProt accession
Q13470, 666 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Non-receptor tyrosine-protein kinase TNK1 |
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| UniProt accession | Q13470 |
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| Gene | TNK1 |
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| Organism | Homo sapiens |
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| Length | 666 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (126)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.21
- Alzheimer disease · score 0.12
- frontotemporal dementia · score 0.12
- tumor predisposition syndrome 2 · score 0.07
- epidermodysplasia verruciformis · score 0.07
- myofibromatosis, infantile, 1 · score 0.07
- Familial adenomatous polyposis · score 0.07
- attenuated familial adenomatous polyposis · score 0.07
- neoplasm · score 0.07
- reticulum cell sarcoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13470-F1 | alphafold | PREDICTED | 72.46 | — |
Amino-acid sequence (666 residues)
MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLS EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL PEPEGGLKCL IPEGAVCRGE LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL RVGPEGPMGT ELGDFLREVS VMMNLEHPHV LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR ALYSLALRCW APHPADRPSF SHLEGLLQEA GPSEACCVRD VTEPGALRME TGDPITVIEG SSSFHSPDST IWKGQNGRTF KVGSFPASAV TLADAGGLPA TRPVHRGTPA RGDQHPGSID GDRKKANLWD APPARGQRRN MPLERMKGIS RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP PLSSSSPQPS QPSRERLPWP KRKPPHNHPM GMPGARKAAA LSGGLLSDPE LQRKIMEVEL SVHGVTHQEC QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCWRILEH YQWDLSAASR YVLARP
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