About Dystrophin-related protein 2
Dystrophin-related protein 2 (DRP2) is a protein
from Homo sapiens identified by UniProt accession
Q13474, 957 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Dystrophin-related protein 2 |
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| UniProt accession | Q13474 |
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| Gene | DRP2 |
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| Organism | Homo sapiens |
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| Length | 957 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (12)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type X · score 0.12
- hereditary motor and sensory neuropathy · score 0.12
- Global developmental delay · score 0.11
- Down syndrome · score 0.02
- polyneuropathy · score 0.02
- Charcot-Marie-Tooth disease · score 0.02
- neuropathy · score 0.00
- endometrial carcinoma · score 0.00
- uterine leiomyosarcoma · score 0.00
- Neurodevelopmental disorder · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13474-F1 | alphafold | PREDICTED | 73.21 | — |
Amino-acid sequence (957 residues)
MQPMVMQGCP YTLPRCHDWQ AADQFHHSSS LRSTCPHPQV RAAVTSPAPP QDGAGVPCLS LKLLNGSVGA SGPLEPPAMN LCWNEIKKKS HNLRARLEAF SDHSGKLQLP LQEIIDWLSQ KDEELSAQLP LQGDVALVQQ EKETHAAFME EVKSRGPYIY SVLESAQAFL SQHPFEELEE PHSESKDTSP KQRIQNLSRF VWKQATVASE LWEKLTARCV DQHRHIERTL EQLLEIQGAM EELSTTLSQA EGVRATWEPI GDLFIDSLPE HIQAIKLFKE EFSPMKDGVK LVNDLAHQLA ISDVHLSMEN SQALEQINVR WKQLQASVSE RLKQLQDAHR DFGPGSQHFL SSSVQVPWER AISPNKVPYY INHQAQTTCW DHPKMTELYQ TLADLNNIKF SAYRTAMKLR RVQKALRLDL VTLTTALEIF NEHDLQASEH VMDVVEVIHC LTALYERLEE ERGILVNVPL CVDMSLNWLL NVFDSGRSGK MRALSFKTGI ACLCGTEVKE KLQYLFSQVA NSGSQCDQRH LGVLLHEAIQ VPRQLGEVAA FGGSNVEPSV RSCFRFSTGK PVIEASQFLE WVNLEPQSMV WLAVLHRVTI AEQVKHQTKC SICRQCPIKG FRYRSLKQFN VDICQTCFLT GRASKGNKLH YPIMEYYTPT TSSENMRDFA TTLKNKFRSK HYFSKHPQRG YLPVQSVLEA DYSETPASSP MWPHADTHSR IEHFASRLAE MESQNCSFFN DSLSPDDSID EDQYLLRHSS PITDREPAFG QQAPCSVATE SKGELQKILA HLEDENRILQ GELRRLKWQH EEAAEAPSLA DGSTEAATDH RNEELLAEAR ILRQHKSRLE TRMQILEDHN KQLESQLQRL RELLLQPPTE SDGSGSAGSS LASSPQQSEG SHPREKGQTT PDTEAADDVG SKSQDVSLCL EDIMEKLRHA FPSVRSSDVT ANTLLAS
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