Mucosal addressin cell adhesion molecule 1 (MADCAM1)

About Mucosal addressin cell adhesion molecule 1

Mucosal addressin cell adhesion molecule 1 (MADCAM1) is a protein from Homo sapiens identified by UniProt accession Q13477, 382 residues long. MolForge cross-references it against 0 known binders and 218 disease associations.

Target properties

Protein name	Mucosal addressin cell adhesion molecule 1
UniProt accession	Q13477
Gene	MADCAM1
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (218)

Diseases linked to this target (Open Targets).

ulcerative colitis · score 0.38
Crohn's disease · score 0.38
type 1 diabetes mellitus · score 0.23
experimental autoimmune encephalomyelitis · score 0.08
hepatocellular carcinoma · score 0.07
common variable immunodeficiency · score 0.06
isolated agammaglobulinemia · score 0.06
BENTA disease · score 0.06
combined immunodeficiency with skin granulomas · score 0.05
hyper-IgM syndrome type 3 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13477-F1	alphafold	PREDICTED	74.63	—

Amino-acid sequence (382 residues)

MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA CADRGASVQW RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG RTFQHTVQLL VYAFPDQLTV SPAALVPGDP EVACTAHKVT PVDPNALSFS LLVGGQELEG AQALGPEVQE EEEEPQGDED VLFRVTERWR LPPLGTPVPP ALYCQATMRL PGLELSHRQA IPVLHSPTSP EPPDTTSPES PDTTSPESPD TTSQEPPDTT SPEPPDKTSP EPAPQQGSTH TPRSPGSTRT RRPEISQAGP TQGEVIPTGS SKPAGDQLPA ALWTSSAVLG LLLLALPTYH LWKRCRHLAE DDTHPPASLR LLPQVSAWAG LRGTGQVGIS PS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards