Interleukin-18 receptor 1 (IL18R1)

About Interleukin-18 receptor 1

Interleukin-18 receptor 1 (IL18R1) is a protein from Homo sapiens identified by UniProt accession Q13478, 541 residues long. MolForge cross-references it against 0 known binders and 347 disease associations.

Target properties

Protein name	Interleukin-18 receptor 1
UniProt accession	Q13478
Gene	IL18R1
Organism	Homo sapiens
Length	541 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (347)

Diseases linked to this target (Open Targets).

Ascending aortic dissection · score 0.50
asthma · score 0.50
eosinophil count · score 0.50
interleukin 1 receptor-like 1 measurement · score 0.47
childhood onset asthma · score 0.47
Behcet's syndrome · score 0.47
blood protein measurement · score 0.46
eosinophil percentage of leukocytes · score 0.46
allergic disease · score 0.46
ST2 protein measurement · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13478-F1	alphafold	PREDICTED	79.28	—

Amino-acid sequence (541 residues)

MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE TTTKSWYKSS GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM KNYTQKWKLN VIRRNKHSCF TERQVTSKIV EVKKFFQITC ENSYYQTLVN STSLYKNCKK LLLENNKNPT IKKNAEFEDQ GYYSCVHFLH HNGKLFNITK TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL LNEEDVIYWM FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI YRVDLVLFYR HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL PRVLEKHFGY KLCIFERDVV PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN EVRYELESGL HEALVERKIK IILIEFTPVT DFTFLPQSLK LLKSHRVLKW KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards