About GRB2-associated-binding protein 1
GRB2-associated-binding protein 1 (GAB1) is a protein
from Homo sapiens identified by UniProt accession
Q13480, 694 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | GRB2-associated-binding protein 1 |
|---|
| UniProt accession | Q13480 |
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| Gene | GAB1 |
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| Organism | Homo sapiens |
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| Length | 694 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (131)
Diseases linked to this target (Open Targets).
- cancer · score 0.59
- bone development disease · score 0.56
- sex hormone-binding globulin measurement · score 0.50
- protein measurement · score 0.44
- hearing loss, autosomal recessive · score 0.37
- creatinine measurement · score 0.35
- vital capacity · score 0.35
- cystatin C measurement · score 0.35
- serum urea measurement · score 0.34
- serum albumin measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13480-F1 | alphafold | PREDICTED | 52.61 | — |
Amino-acid sequence (694 residues)
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT EEDPVKPPGS SLQAPADLPL AINTAPPSTQ ADSSSATLPP PYQLINVPPH LETLGIQEDP QDYLLLINCQ SKKPEPTRTH ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM IYDSPPSRAP SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP AHDRSPVETC SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA SSQDCYDIPR AFPSDRSSSL EGFHNHFKVK NVLTVGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VADCEPPPVD RNLKPDRKVK PAPLEIKPLP EWEELQAPVR SPITRSFARD SSRFPMSPRP DSVHSTTSSS DSHDSEENYV PMNPNLSSED PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV VVDQQKTLAL KSTREAWTDG RQSTESETPA KSVK
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