About Baculoviral IAP repeat-containing protein 3
Baculoviral IAP repeat-containing protein 3 (BIRC3) is a protein
from Homo sapiens identified by UniProt accession
Q13489, 604 residues long.
MolForge cross-references it against 0 known binders and
499 disease associations.
Target properties
| Protein name | Baculoviral IAP repeat-containing protein 3 |
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| UniProt accession | Q13489 |
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| Gene | BIRC3 |
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| Organism | Homo sapiens |
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| Length | 604 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (499)
Diseases linked to this target (Open Targets).
- chronic lymphocytic leukemia · score 0.45
- marginal zone B-cell lymphoma · score 0.37
- multiple myeloma · score 0.37
- Mantle cell lymphoma · score 0.37
- cutaneous melanoma · score 0.37
- skin basal cell carcinoma · score 0.37
- skin squamous cell carcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- hepatocellular carcinoma · score 0.30
- oral squamous cell carcinoma · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13489-F1 | alphafold | PREDICTED | 74.78 | — |
Amino-acid sequence (604 residues)
MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ DTSRYTVSNL SMQTHAARFK TFFNWPSSVL VNPEQLASAG FYYVGNSDDV KCFCCDGGLR CWESGDDPWV QHAKWFPRCE YLIRIKGQEF IRQVQASYPH LLEQLLSTSD SPGDENAESS IIHFEPGEDH SEDAIMMNTP VINAAVEMGF SRSLVKQTVQ RKILATGENY RLVNDLVLDL LNAEDEIREE ERERATEEKE SNDLLLIRKN RMALFQHLTC VIPILDSLLT AGIINEQEHD VIKQKTQTSL QARELIDTIL VKGNIAATVF RNSLQEAEAV LYEHLFVQQD IKYIPTEDVS DLPVEEQLRR LQEERTCKVC MDKEVSIVFI PCGHLVVCKD CAPSLRKCPI CRSTIKGTVR TFLS
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