About Baculoviral IAP repeat-containing protein 2
Baculoviral IAP repeat-containing protein 2 (BIRC2) is a protein
from Homo sapiens identified by UniProt accession
Q13490, 618 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | Baculoviral IAP repeat-containing protein 2 |
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| UniProt accession | Q13490 |
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| Gene | BIRC2 |
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| Organism | Homo sapiens |
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| Length | 618 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (260)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- glioblastoma multiforme · score 0.28
- pancreatic adenocarcinoma · score 0.27
- breast adenocarcinoma · score 0.27
- endometrial cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.16
- hepatocellular carcinoma · score 0.15
- gastric adenocarcinoma · score 0.13
- chronic lymphocytic leukemia · score 0.13
- neoplasm · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13490-F1 | alphafold | PREDICTED | 76.60 | — |
Amino-acid sequence (618 residues)
MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR KCPICRGIIK GTVRTFLS
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