About Neuronal membrane glycoprotein M6-b
Neuronal membrane glycoprotein M6-b (GPM6B) is a protein
from Homo sapiens identified by UniProt accession
Q13491, 265 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Neuronal membrane glycoprotein M6-b |
|---|
| UniProt accession | Q13491 |
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| Gene | GPM6B |
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| Organism | Homo sapiens |
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| Length | 265 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- delayed reward discounting measurement · score 0.33
- hepatocellular carcinoma · score 0.06
- breast carcinoma · score 0.03
- neoplasm · score 0.03
- cancer · score 0.02
- Abnormal sperm morphology · score 0.02
- melanoma · score 0.02
- non-small cell lung carcinoma · score 0.02
- medulloblastoma · score 0.02
- clear cell renal carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13491-F1 | alphafold | PREDICTED | 82.30 | — |
Amino-acid sequence (265 residues)
MKPAMETAAE ENTEQSQERK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL IYMMATTYNY AVLKFKSRED CCTKF
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