About Phosphatidylinositol-binding clathrin assembly protein
Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a protein
from Homo sapiens identified by UniProt accession
Q13492, 652 residues long.
MolForge cross-references it against 0 known binders and
293 disease associations.
Target properties
| Protein name | Phosphatidylinositol-binding clathrin assembly protein |
|---|
| UniProt accession | Q13492 |
|---|
| Gene | PICALM |
|---|
| Organism | Homo sapiens |
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| Length | 652 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (293)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.39
- platelet count · score 0.37
- family history of Alzheimer’s disease · score 0.36
- mean platelet volume · score 0.35
- acute myeloid leukemia · score 0.28
- mean corpuscular hemoglobin concentration · score 0.27
- Immature Reticulocyte Fraction Measurement · score 0.27
- Red cell distribution width · score 0.27
- reticulocyte count · score 0.27
- erythrocyte count · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13492-F1 | alphafold | PREDICTED | 66.21 | — |
Amino-acid sequence (652 residues)
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM
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