Myotubularin (MTM1)

About Myotubularin

Myotubularin (MTM1) is a protein from Homo sapiens identified by UniProt accession Q13496, 603 residues long. MolForge cross-references it against 0 known binders and 422 disease associations.

Target properties

Protein name	Myotubularin
UniProt accession	Q13496
Gene	MTM1
Organism	Homo sapiens
Length	603 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (422)

Diseases linked to this target (Open Targets).

X-linked myotubular myopathy · score 0.86
centronuclear myopathy · score 0.45
Generalized hypotonia · score 0.43
myopathy · score 0.35
neurodegenerative disease · score 0.35
Polyhydramnios · score 0.34
Neonatal hypotonia · score 0.34
Decreased fetal movement · score 0.34
High palate · score 0.34
Neurodevelopmental disorder · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13496-F1	alphafold	PREDICTED	89.74	—

Amino-acid sequence (603 residues)

MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDMRNLR FALKQEGHSR RDMFEILTRY AFPLAHSLPL FAFLNEEKFN VDGWTVYNPV EEYRRQGLPN HHWRITFINK CYELCDTYPA LLVVPYRASD DDLRRVATFR SRNRIPVLSW IHPENKTVIV RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ ISKLTIYDAR PSVNAVANKA TGGGYESDDA YHNAELFFLD IHNIHVMRES LKKVKDIVYP NVEESHWLSS LESTHWLEHI KLVLTGAIQV ADKVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRSI EGFEILVQKE WISFGHKFAS RIGHGDKNHT DADRSPIFLQ FIDCVWQMSK QFPTAFEFNE QFLIIILDHL YSCRFGTFLF NCESARERQK VTERTVSLWS LINSNKEKFK NPFYTKEINR VLYPVASMRH LELWVNYYIR WNPRIKQQQP NPVEQRYMEL LALRDEYIKR LEELQLANSA KLSDPPTSPS SPSQMMPHVQ THF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards