Mediator of RNA polymerase II transcription subunit…

About Mediator of RNA polymerase II transcription subunit 21

Mediator of RNA polymerase II transcription subunit 21 (MED21) is a protein from Homo sapiens identified by UniProt accession Q13503, 144 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Mediator of RNA polymerase II transcription subunit 21
UniProt accession	Q13503
Gene	MED21
Organism	Homo sapiens
Length	144 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
mathematical ability · score 0.19
systolic blood pressure · score 0.18
self reported educational attainment · score 0.17
diastolic blood pressure · score 0.15
blood pressure · score 0.09
neoplasm · score 0.02
Alzheimer disease · score 0.01
Cafe-au-lait spot · score 0.01
cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13503-F1	alphafold	PREDICTED	84.97	—

Amino-acid sequence (144 residues)

MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFNNIQT AINKDQPANP TEEYAQLFAA LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA ATCLEDVVYR GDMLLEKIQS ALADIAQSQL KTRSGTHSQS LPDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Mediator of RNA polymerase II transcription subunit 21 (MED21)