About Metaxin-1
Metaxin-1 (MTX1) is a protein
from Homo sapiens identified by UniProt accession
Q13505, 466 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Metaxin-1 |
|---|
| UniProt accession | Q13505 |
|---|
| Gene | MTX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 466 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- Parkinson disease · score 0.24
- multiple sclerosis · score 0.24
- Alzheimer disease · score 0.24
- lysosomal storage disease · score 0.24
- gastric carcinoma · score 0.17
- blood urea nitrogen measurement · score 0.17
- hematocrit · score 0.17
- glomerular filtration rate · score 0.16
- hemoglobin measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13505-F1 | alphafold | PREDICTED | 70.98 | — |
Amino-acid sequence (466 residues)
MLLGGPPRSP RSGTSPKGPW SSTGHVQFGK SPQTWPRRTR PRSPEPAAPS GVRGSTWTRR RDSPRRAGPT ALSRYVGHLW MGRRPPSPEA RGPVPRSSAA SRARRSLASP GISPGPLTAT IGGAVAGGGP RQGRAEAHKE VFPGQRVGKM AAPMELFCWS GGWGLPSVDL DSLAVLTYAR FTGAPLKVHK ISNPWQSPSG TLPALRTSHG EVISVPHKII THLRKEKYNA DYDLSARQGA DTLAFMSLLE EKLLPVLVHT FWIDTKNYVE VTRKWYAEAM PFPLNFFLPG RMQRQYMERL QLLTGEHRPE DEEELEKELY REARECLTLL SQRLGSQKFF FGDAPASLDA FVFSYLALLL QAKLPSGKLQ VHLRGLHNLC AYCTHILSLY FPWDGAEVPP QRQTPAGPET EEEPYRRRNQ ILSVLAGLAA MVGYALLSGI VSIQRATPAR APGTRTLGMA EEDEEE
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