NGFI-A-binding protein 1 (NAB1)

About NGFI-A-binding protein 1

NGFI-A-binding protein 1 (NAB1) is a protein from Homo sapiens identified by UniProt accession Q13506, 487 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	NGFI-A-binding protein 1
UniProt accession	Q13506
Gene	NAB1
Organism	Homo sapiens
Length	487 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.43
primary biliary cirrhosis · score 0.41
systolic blood pressure · score 0.41
heel bone mineral density · score 0.38
systemic scleroderma · score 0.38
rheumatoid arthritis · score 0.37
systemic lupus erythematosus · score 0.36
autoimmune disease · score 0.30
biliary liver cirrhosis · score 0.30
myositis · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13506-F1	alphafold	PREDICTED	64.40	—

Amino-acid sequence (487 residues)

MAAALPRTLG ELQLYRILQK ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL EIMALVGMAS KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP EGSPTWLGIS CSSYERSSNA REPHLKIPKC AATTCVQSLG QGKSDVVGSL ALQSVGESRL WQGHHATESE HSLSPADLGS PASPKESSEA LDAAAALSVA ECVERMAPTL PKSDLNEVKE LLKTNKKLAK MIGHIFEMND DDPHKEEEIR KYSAIYGRFD SKRKDGKHLT LHELTVNEAA AQLCVKDNAL LTRRDELFAL ARQISREVTY KYTYRTTKSK CGERDELSPK RIKVEDGFPD FQDSVQTLFQ QARAKSEELA ALSSQQPEKV MAKQMEFLCN QAGYERLQHA ERRLSAGLYR QSSEEHSPNG LTSDNSDGQG ERPLNLRMPN LQNRQPHHFV VDGELSRLYP SEAKSHSSES LGILKDYPHS AFTLEKKVIK TEPEDSR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards