Ecto-ADP-ribosyltransferase 3 (ART3)

About Ecto-ADP-ribosyltransferase 3

Ecto-ADP-ribosyltransferase 3 (ART3) is a protein from Homo sapiens identified by UniProt accession Q13508, 389 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Ecto-ADP-ribosyltransferase 3
UniProt accession	Q13508
Gene	ART3
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.30
protein measurement · score 0.25
body mass index · score 0.25
mean corpuscular hemoglobin concentration · score 0.22
mean corpuscular hemoglobin · score 0.20
CXCL11 measurement · score 0.19
C-X-C motif chemokine 11 measurement · score 0.18
apolipoprotein A 1 measurement · score 0.16
fetal genotype effect measurement · score 0.14
type 2 diabetes mellitus · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13508-F1	alphafold	PREDICTED	74.01	—

Amino-acid sequence (389 residues)

MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF GHFTLAYSAK PQAANDQLTV LSIYTCLGVD IENFLDKESE RITLIPLNEV FQVSQEGAGN NLILQSINKT CSHYECAFLG GLKTENCIEN LEYFQPIYVY NPGEKNQKLE DHSEKNWKLE DHGEKNQKLE DHGVKILEPT QIPGMKIPEP FPLPEDKSQG NINNPTPGPV PVPGPKSHPS ASSGKLLLPQ FGMVIILISV SAINLFVAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards