About Tubulin beta-3 chain
Tubulin beta-3 chain (TUBB3) is a protein
from Homo sapiens identified by UniProt accession
Q13509, 450 residues long.
MolForge cross-references it against 0 known binders and
681 disease associations.
Target properties
| Protein name | Tubulin beta-3 chain |
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| UniProt accession | Q13509 |
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| Gene | TUBB3 |
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| Organism | Homo sapiens |
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| Length | 450 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (681)
Diseases linked to this target (Open Targets).
- fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement · score 0.78
- Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation · score 0.77
- complex cortical dysplasia with other brain malformations 1 · score 0.74
- congenital fibrosis of the extraocular muscles · score 0.71
- neoplasm · score 0.62
- non-small cell lung carcinoma · score 0.62
- prostate cancer · score 0.62
- breast cancer · score 0.61
- head and neck squamous cell carcinoma · score 0.61
- pancreatic adenocarcinoma · score 0.61
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13509-F1 | alphafold | PREDICTED | 91.45 | — |
Amino-acid sequence (450 residues)
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPSGNYVGDS DLQLERISVY YNEASSHKYV PRAILVDLEP GTMDSVRSGA FGHLFRPDNF IFGQSGAGNN WAKGHYTEGA ELVDSVLDVV RKECENCDCL QGFQLTHSLG GGTGSGMGTL LISKVREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSIH QLVENTDETY CIDNEALYDI CFRTLKLATP TYGDLNHLVS ATMSGVTTSL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTARGSQQ YRALTVPELT QQMFDAKNMM AACDPRHGRY LTVATVFRGR MSMKEVDEQM LAIQSKNSSY FVEWIPNNVK VAVCDIPPRG LKMSSTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEGEMYEDD EEESEAQGPK
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