Phakinin (BFSP2)

About Phakinin

Phakinin (BFSP2) is a protein from Homo sapiens identified by UniProt accession Q13515, 415 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Phakinin
UniProt accession	Q13515
Gene	BFSP2
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

cataract 12 multiple types · score 0.76
Partial congenital cataract · score 0.71
pulverulent cataract · score 0.38
Cataract · score 0.38
early-onset sutural cataract · score 0.37
cataract · score 0.36
Intellectual disability · score 0.34
Strabismus · score 0.34
Seizure · score 0.34
Global developmental delay · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13515-F1	alphafold	PREDICTED	76.86	—

Amino-acid sequence (415 residues)

MSERRVVVDL PTSASSSMPL QRRRASFRGP RSSSSLESPP ASRTNAMSGL VRAPGVYVGT APSGCIGGLG ARVTRRALGI SSVFLQGLRS SGLATVPAPG LERDHGAVED LGGCLVEYMA KVHALEQVSQ ELETQLRMHL ESKATRSGNW GALRASWASS CQQVGEAVLE NARLMLQTET IQAGADDFKE RYENEQPFRK AAEEEINSLY KVIDEANLTK MDLESQIESL KEELGSLSRN YEEDVKLLHK QLAGCELEQM DAPIGTGLDD ILETIRIQWE RDVEKNRVEA GALLQAKQQA EVAHMSQTQE EKLAAALRVE LHNTSCQVQS LQAETESLRA LKRGLENTLH DAKHWHDMEL QNLGAVVGRL EAELREIRAE AEQQQQERAH LLARKCQLQK DVASYHALLD REESG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards