Oligodendrocyte transcription factor 2 (OLIG2)

About Oligodendrocyte transcription factor 2

Oligodendrocyte transcription factor 2 (OLIG2) is a protein from Homo sapiens identified by UniProt accession Q13516, 323 residues long. MolForge cross-references it against 0 known binders and 287 disease associations.

Target properties

Protein name	Oligodendrocyte transcription factor 2
UniProt accession	Q13516
Gene	OLIG2
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (287)

Diseases linked to this target (Open Targets).

colorectal adenocarcinoma · score 0.37
colon adenocarcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
self reported educational attainment · score 0.31
small cell lung carcinoma · score 0.28
hepatocellular carcinoma · score 0.28
lung adenocarcinoma · score 0.28
gastric carcinoma · score 0.28
breast carcinoma · score 0.28
esophageal adenocarcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13516-F1	alphafold	PREDICTED	58.99	—

Amino-acid sequence (323 residues)

MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE LSAELRGAMG SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV PPPHHHVSAM GAGSLPRLTS DAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards