About Prepronociceptin
Prepronociceptin (PNOC) is a protein
from Homo sapiens identified by UniProt accession
Q13519, 176 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Prepronociceptin |
|---|
| UniProt accession | Q13519 |
|---|
| Gene | PNOC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 176 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (106)
Diseases linked to this target (Open Targets).
- body mass index · score 0.33
- daytime rest measurement · score 0.28
- type 2 diabetes mellitus · score 0.23
- optic cup area measurement · score 0.23
- birth weight · score 0.17
- thyroid gland adenocarcinoma · score 0.16
- neurodegenerative disease · score 0.15
- adolescent idiopathic scoliosis · score 0.05
- ulcerative colitis · score 0.03
- anxiety · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13519-F1 | alphafold | PREDICTED | 62.90 | — |
Amino-acid sequence (176 residues)
MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE KVFPSPLWTP CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR VRSLFQEQEE PEPGMEEAGE MEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNV
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