About Aquaporin-6
Aquaporin-6 (AQP6) is a protein
from Homo sapiens identified by UniProt accession
Q13520, 282 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Aquaporin-6 |
|---|
| UniProt accession | Q13520 |
|---|
| Gene | AQP6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 282 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- forced expiratory volume · score 0.06
- X-linked retinal dysplasia · score 0.04
- Senior-Loken syndrome 7 · score 0.03
- low density lipoprotein cholesterol measurement · score 0.03
- gastric cancer · score 0.03
- malignant pleural mesothelioma · score 0.03
- Kidney Oncocytoma · score 0.03
- colorectal adenocarcinoma · score 0.02
- Meniere disease · score 0.02
- ovarian serous adenocarcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13520-F1 | alphafold | PREDICTED | 87.49 | — |
Amino-acid sequence (282 residues)
MDAVEPGGRG WASMLACRLW KAISRALFAE FLATGLYVFF GVGSVMRWPT ALPSVLQIAI TFNLVTAMAV QVTWKASGAH ANPAVTLAFL VGSHISLPRA VAYVAAQLVG ATVGAALLYG VMPGDIRETL GINVVRNSVS TGQAVAVELL LTLQLVLCVF ASTDSRQTSG SPATMIGISV ALGHLIGIHF TGCSMNPARS FGPAIIIGKF TVHWVFWVGP LMGALLASLI YNFVLFPDTK TLAQRLAILT GTVEVGTGAG AGAEPLKKES QPGSGAVEME SV
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