About Protein phosphatase 1 regulatory subunit 1A
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a protein
from Homo sapiens identified by UniProt accession
Q13522, 171 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 1A |
|---|
| UniProt accession | Q13522 |
|---|
| Gene | PPP1R1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 171 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- rosette-forming glioneuronal tumor of fourth ventricule · score 0.12
- Ewing sarcoma · score 0.05
- hepatocellular carcinoma · score 0.04
- colorectal cancer · score 0.04
- glioblastoma multiforme · score 0.03
- Acute hepatic failure · score 0.03
- clear cell renal carcinoma · score 0.03
- astrocytoma · score 0.03
- neoplasm · score 0.03
- lower respiratory tract disease · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q13522-F1 | alphafold | PREDICTED | 66.53 | — |
Amino-acid sequence (171 residues)
MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS V
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