Peptidyl-prolyl cis-trans isomerase…

About Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a protein from Homo sapiens identified by UniProt accession Q13526, 163 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
UniProt accession	Q13526
Gene	PIN1
Organism	Homo sapiens
Length	163 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (111)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.25
head and neck squamous cell carcinoma · score 0.25
physical activity measurement · score 0.25
gastric adenocarcinoma · score 0.23
sleep duration · score 0.21
age at menarche · score 0.17
appendicular lean mass · score 0.16
vital capacity · score 0.14
IGF-1 measurement · score 0.10
melanoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13526-F1	alphafold	PREDICTED	91.61	—

Amino-acid sequence (163 residues)

MADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGN SSSGGKNGQG EPARVRCSHL LVKHSQSRRP SSWRQEKITR TKEEALELIN GYIQKIKSGE EDFESLASQF SDCSSAKARG DLGAFSRGQM QKPFEDASFA LRTGEMSGPV FTDSGIHIIL RTE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)