Eukaryotic translation initiation factor 4E-binding…

About Eukaryotic translation initiation factor 4E-binding protein 1

Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) is a protein from Homo sapiens identified by UniProt accession Q13541, 118 residues long. MolForge cross-references it against 0 known binders and 376 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 4E-binding protein 1
UniProt accession	Q13541
Gene	EIF4EBP1
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (376)

Diseases linked to this target (Open Targets).

age at menopause · score 0.22
neurodegenerative disease · score 0.17
menopause · score 0.16
neoplasm · score 0.11
cancer · score 0.10
nonpapillary renal cell carcinoma · score 0.09
hepatocellular carcinoma · score 0.09
non-small cell lung carcinoma · score 0.09
renal cell carcinoma · score 0.09
breast cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13541-F1	alphafold	PREDICTED	71.41	—

Amino-acid sequence (118 residues)

MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)